Monday Night Football: Bills vs Titans Week 6 Odds and Preview

Sunday’s bundle of Week 6 NFL games are officially in the books, meaning that fans are now turning their attention to an exciting Monday Night Football contest. This week’s game is a matchup between a pair of AFC teams as the Buffalo Bills (4-1) take on the Tennessee Titans (3-2). Both teams will be looking to improve their spots in the standings with a victory tonight, which should make for some entertaining football action.

There’s a lot to take account of before tonight’s Monday Night Football clash, so continue reading this guide for the betting odds heading into the matchup — with odds courtesy of BetOnline.

Bills vs Titans General Information and Statistics

Tonight’s game will be held at Nissan Stadium in Nashville, Tennessee, where the Titans currently have a home record of 1-1. Kickoff is scheduled for 8:15 p.m. EST and the contest itself can be viewed on ESPN and other streaming platforms around the world.

The Bills are currently averaging 34.4 points per game, which is the No. 1 average in the NFL. Meanwhile, Titans are averaging 26.4 PPG — the eighth-best average. Defensively, Buffalo is allowing 12.8 PPG (1st) while Tennessee is surrendering 26.0 PPG (24th).

Monday Night Football: Bills vs Titans Odds

Odds via BetOnline as of Monday, October 18

  • Buffalo Bills (4-1) vs Tennessee Titans (3-2)
  • Moneyline: Bills (-255) vs Titans (+215)
  • Spread: Bills -9.0 (-117) vs Titans +9.0 (-103)
  • Total: 53.5 — Over (-105), Under (-115)

A complete list of odds and prop markets is available at

Bills Enter With Top Offense, Defense

With the top-ranked offense and defense in the NFL, it’s hard not to view the Bills (-255) as the best team in the league. After a season-opening loss to the Pittsburgh Steelers, Buffalo has looked close to unbeatable since then.

Now, the Bills are entering this Monday Night Football matchup as they’re coming off a huge 38-20 victory over the Kansas City Chiefs in Week 5. Quarterback Josh Allen was the star of the show, throwing for 315 passing yards and a trio of touchdowns. A good portion of his work was done with tight end Dawson Knox, who ended the night with three receptions for a massive 117 yards and a touchdown. The Titans are giving up the 10th-most passing yards per game this year (264.6), so Buffalo’s pass-catchers should see a lot of activity tonight.

The thing about Buffalo is how surprisingly good its defense has been this year. After what happened at the 2020 AFC Championship Game, it’d be unthinkable to imagine the Bills holding the Chiefs to just 20 points, but it happened last week. Now, Buffalo takes on Tennessee, who certainly doesn’t have Kansas City’s offense. Both of the Titans’ top wideouts are less than 100% (more on that later) and the Bills are one of the best teams at stopping the run.

All in all, it’s hard imagining Buffalo leaving Nashville without the victory.

Titans Monday Night Football Odds

During the offseason, there was talk about the Titans potentially having one of the top offenses in the NFL after acquiring wide receiver Julio Jones from the Atlanta Falcons.

While Tennessee is still putting up a lot of points this season, it’s rarely come from their passing game. Jones has been at less than 100% health this season and has 12 receptions for 204 passing yards and no touchdowns through three games. Meanwhile, A.J. Brown hasn’t been any better, logging a disappointing 10-130-1 stat line after his first four games. The Titans need their duo to turn things around as soon as possible, however, that may be tough against a Buffalo secondary that’s allowing an NFL-low 173.4 passing yards per game. It also doesn’t help that Brown is questionable for tonight’s game with an illness.

At the end of the day, it could be another Derrick Henry-centric game for Tennessee. The Titans running back has once again been the best at his position this season, leading the NFL in total touches (156), yards from scrimmage (765) and total touchdowns (7). Aside from Week 1, Henry has rushed for at least 113 yards every week.

Nevertheless, he’ll come face-to-face with a Bills defense that’s allowed the fewest rushing yards (249) so far and is the only team left that hasn’t allowed a TD on the ground. Obviously, Henry isn’t your ordinary running back, but that doesn’t change the fact that he could be in for a rough night.

Devon Platana
Devon Platana

After graduating with a Masters degree in Journalism, Devon joined USGS to improve his sports writing skills. As a lifelong sports fan, one of Devon’s favorite things to do is analyze statistics across all sports.