Monday Night Football: Rams vs 49ers Week 10 Odds and Preview

Sunday’s bundle of Week 10 NFL games are officially in the books, meaning that fans are now turning their attention to an exciting Monday Night Football contest. This week’s game is an NFC West divisional matchup as the Los Angeles Rams (7-2) take on the San Francisco 49ers (3-5). Both teams will be looking to improve their spots in the standings with a victory tonight, which should make for some entertaining football action.

There’s a lot to take account of before tonight’s Monday Night Football clash, so continue reading this guide for the betting odds heading into the matchup — with odds courtesy of BetOnline.

Rams vs 49ers General Information and Statistics

Tonight’s game will be held at Levi’s Stadium in Santa Clara, California, where the 49ers currently have a home record of 0-4. Kickoff is scheduled for 8:15 p.m. EST and the contest itself can be viewed on ESPN and other streaming platforms around the world.

The Rams are currently averaging 29.0 points per game, which is the fourth-best average in the NFL. Meanwhile, the 49ers are averaging 23.1 PPG — the 17th-best average. Defensively, Los Angeles is allowing 21.8 PPG (11th) while San Francisco is surrendering 25.2 PPG (24th).

Monday Night Football: Rams vs 49ers Odds

Odds via BetOnline as of Monday, November 15

  • Los Angeles Rams (7-2) vs San Francisco 49ers (3-5)
  • Moneyline: Rams (-190) vs 49ers (+165)
  • Spread: Rams -3.5 (-108) vs 49ers +3.5 (-112)
  • Total: 50.0 — Over (-115), Under (-105)
  • Head-to-Head: The 49ers are 7-3 against the Rams in their last 10 matchups.

A complete list of odds and prop markets is available at

Rams Prepare for Life Without Woods

The Rams were the winners of the Odell Beckham Jr. sweepstakes last week, making their passing offense more elite than it already was. Unfortunately, that dream came to a stop just a few days later when it was revealed that fellow wideout Roberts Woods sustained a season-ending ACL tear during Friday’s practice. Not only was he a great offensive contributor (45-556-4 on 69 targets) but he was also ProFootballFocus’ No. 1-ranked blocking wide receiver this season. Needless to say that Monday Night Football will be the Rams’ first test to see if Beckham can make the loss of Woods easier to swallow.

Nevertheless, this is the first time that the Rams will be playing the 49ers this season. They’re coming off a disappointing 28-16 loss to the Tennessee Titans last week, so they’ll be looking to beat up on an underperforming San Francisco squad.

Monday Night Football could figure to be a big game for Darrell Henderson. While the 49ers are a Top-5 team against the pass, they’ve surrendered 162.3 rushing yards per game over their last three outings — the most in the NFL during that span. Henderson may also need to be relied on just because the Rams need to ease Beckham into the offense. Teams may also focus more attention on Cooper Kupp during that time as well.

Still, Los Angeles is a better team than the one that lost to the Titans last week. Now, they have a great opportunity to keep pace with the Arizona Cardinals (8-2) if they can leave Santa Clara with the win.

49ers Underdogs in Monday Night Football

The 49ers will enter Week 10’s Monday Night Football matchup as the +165 underdogs, according to BetOnline. That isn’t surprising considering their struggles as of late. San Francisco has lost five of its last six games. Even then, its only win in that stretch came against the lowly Chicago Bears.

Jimmy Garoppolo will once again start under center. He’s been looking good as of late, throwing for 300 yards in each of his last two games. One thing that the 49ers need to do is protect him much better than they did last week. Garoppolo was sacked five times during the loss to the Cardinals and that can’t happen again if San Francisco wants to turn its season around.

The 49ers will be without backup running back JaMycal Hasty, which means that Jeff Wilson Jr. may finally get to make his 2021 on-field debut. He was active for last week’s game, however, he didn’t see any snaps. San Francisco will also be without key pieces such as WR Mohamed Sanu (knee), CB Dre Kirkpatrick (ankle) and DL Maurice Hurst (calf).

It’s certainly going to be an uphill battle for the 49ers, but they’re also 7-3 against the Rams in their last 10 meetings for a reason. Los Angeles is as vulnerable as it’ll ever be with everything that’s gone on over the past few days, which is why it’s crucial for San Francisco can take advantage of any opportunities it gets.

Devon Platana
Devon Platana

After graduating with a Masters degree in Journalism, Devon joined USGS to improve his sports writing skills. As a lifelong sports fan, one of Devon’s favorite things to do is analyze statistics across all sports.