NFL Odds: Lines and Spread for each of Sunday’s Week 1 Games

The 2021 NFL season kicked with an absolute banger of a game as the Tampa Bay Buccaneers edged out the Dallas Cowboys, 31-29, in a high-scoring affair. Now, fans are turning their attention to Sunday as 14 action-packed games are on the schedule.

With so many contests available, it’s tough keeping track of the odds for each game. That’s why this article will take a look at the odds heading into every NFL game scheduled for Sunday, September 12 — with odds courtesy of BetOnline.

NFL Odds: Pittsburgh Steelers vs Buffalo Bills

Odds via BetOnline as of Friday, September 10

  • Record: Pittsburgh Steelers (0-0) vs Buffalo Bills (0-0)
  • Start time: 1 p.m. EST
  • Moneyline: Steelers (+230) vs Bills (-275)
  • Spread: Steelers +6.5 (-110) vs Bills -6.5 (-110)
  • Total: 48.0 — Over (-104), Under (-116)
  • Head-to-Head: Steelers are 7-3 against the Bills in their last 10 games.

New York Jets vs Carolina Panthers

Odds via BetOnline as of Friday, September 10

  • Record: New York Jets (0-0) vs Carolina Panthers (0-0)
  • Start time: 1 p.m. EST
  • Moneyline: Jets (+175) vs Panthers (-205)
  • Spread: Jets +4.0 (-110) vs Panthers -4.0 (-110)
  • Total: 44.5 — Over (-111), Under (-109)
  • Head-to-Head: Panthers are 4-3 against the Jets in their last seven games.

Jacksonville Jaguars vs Houston Texans

Odds via BetOnline as of Friday, September 10

  • Record: Jacksonville Jaguars (0-0) vs Houston Texans (0-0)
  • Start time: 1 p.m. EST
  • Moneyline: Jaguars (-171) vs Texans (+151)
  • Spread: Jaguars -3.0 (-110) vs Texans +3.0 (-110)
  • Total: 45.5 — Over (-110), Under (-110)
  • Head-to-Head: Texans are 8-2 against the Jaguars in their last 10 games.

NFL Odds: Arizona Cardinals vs Tennessee Titans

Odds via BetOnline as of Friday, September 10

  • Record: Arizona Cardinals (0-0) vs Tennessee Titans (0-0)
  • Start time: 1 p.m. EST
  • Moneyline: Cardinals (+135) vs Titans (-155)
  • Spread: Cardinals +3.0 (-115) vs Titans -3.0 (-105)
  • Total: 52.5 — Over (-112), Under (-108)
  • Head-to-Head: Cardinals are 3-2 against the Titans in their last five games.

Los Angeles Chargers vs Washington Football Team

Odds via BetOnline as of Friday, September 10

  • Record: Los Angeles Chargers (0-0) vs Washington Football Team (0-0)
  • Start time: 1 p.m. EST
  • Moneyline: Chargers (N/A) vs Washington (N/A)
  • Spread: Chargers Pick’ Em (+100) vs Washington Pick’ Em (-120)
  • Total: 44.5 — Over (-110), Under (-110)
  • Head-to-Head: Chargers are 4-2 against Washington in their last six games.

Philadelphia Eagles vs Atlanta Falcons

Odds via BetOnline as of Friday, September 10

  • Record: Philadelphia Eagles (0-0) vs Atlanta Falcons (0-0)
  • Start time: 1 p.m. EST
  • Moneyline: Eagles (+157) vs Falcons (-177)
  • Spread: Eagles +3.5 (-113) vs Falcons -3.5 (-107)
  • Total: 48.5 — Over (-115), Under (-105)
  • Head-to-Head: Eagles are 6-4 against the Falcons in their last 10 games.

NFL Odds: Seattle Seahawks vs Indianapolis Colts

Odds via BetOnline as of Friday, September 10

  • Record: Seattle Seahawks (0-0) vs Indianapolis Colts (0-0)
  • Start time: 1 p.m. EST
  • Moneyline: Seahawks (-165) vs Colts (+145)
  • Spread: Seahawks -3.0 (-105) vs Colts +3.0 (-115)
  • Total: 49.0 — Over (-110), Under (-110)
  • Head-to-Head: Seahawks are 4-3 against the Colts in their last seven games.

Minnesota Vikings vs Cincinnati Bengals

Odds via BetOnline as of Friday, September 10

  • Record: Minnesota Vikings (0-0) vs Cincinnati Bengals (0-0)
  • Start time: 1 p.m. EST
  • Moneyline: Vikings (-153) vs Bengals (+133)
  • Spread: Vikings -3.0 (-105) vs Bengals +3.0 (-115)
  • Total: 47.0 — Over (-110), Under (-110)
  • Head-to-Head: Vikings are 3-3 against the Bengals in their last six games.

San Francisco 49ers vs Detroit Lions

Odds via BetOnline as of Friday, September 10

  • Record: San Francisco 49ers (0-0) vs Detroit Lions (0-0)
  • Start time: 1 p.m. EST
  • Moneyline: 49ers (-375) vs Lions (+305)
  • Spread: 49ers -9.0 (-105) vs Lions +9.0 (-115)
  • Total: 45.0 — Over (-107), Under (-113)
  • Head-to-Head: 49ers are 9-1 against the Lions in their last 10 games.

NFL Odds: Cleveland Browns vs Kansas City Chiefs

Odds via BetOnline as of Friday, September 10

  • Record: Cleveland Browns (0-0) vs Kansas City Chiefs (0-0)
  • Start time: 4:25 p.m. EST
  • Moneyline: Browns (+205) vs Chiefs (-245)
  • Spread: Browns +5.5 (-111) vs Chiefs -5.5 (-109)
  • Total: 54.5 — Over (-117), Under (-103)
  • Head-to-Head: Chiefs are 7-3 against the Browns in their last 10 games.

Miami Dolphins vs New England Patriots

Odds via BetOnline as of Friday, September 10

  • Record: Miami Dolphins (0-0) vs New England Patriots (0-0)
  • Start time: 4:25 p.m. EST
  • Moneyline: Dolphins (+155) vs Patriots (-175)
  • Spread: Dolphins +3.0 (+100) vs Patriots -3.0 (-120)
  • Total: 43.5 — Over (-105), Under (-115)
  • Head-to-Head: Patriots are 6-4 against the Dolphins in their last 10 games.

Denver Broncos vs New York Giants

Odds via BetOnline as of Friday, September 10

  • Record: Denver Broncos (0-0) vs New York Giants (0-0)
  • Start time: 4:25 p.m. EST
  • Moneyline: Broncos (-158) vs Giants (+138)
  • Spread: Broncos -3.0 (-105) vs Giants +3.0 (-115)
  • Total: 41.5 — Over (-110), Under (-110)
  • Head-to-Head: Broncos are 3-3 against the Giants in their last six games.

NFL Odds: Green Bay Packers vs New Orleans Saints

Odds via BetOnline as of Friday, September 10

  • Record: Green Bay Packers (0-0) vs New Orleans Saints (0-0)
  • Start time: 4:25 p.m. EST
  • Moneyline: Packers (-175) vs Saints (+155)
  • Spread: Packers -3.5 (-105) vs Saints +3.5 (-115)
  • Total: 49.5 — Over (-110), Under (-110)
  • Head-to-Head: Packers are 5-5 against the Saints in their last 10 games.

Sunday Night Football Odds: Chicago Bears vs Los Angeles Rams

Odds via BetOnline as of Friday, September 10

  • Record: Chicago Bears (0-0) vs Los Angeles Rams (0-0)
  • Start time: 8:20 p.m. EST
  • Moneyline: Bears (+280) vs Rams (-350)
  • Spread: Bears +9.0 (-125) vs Rams -9.0 (+105)
  • Total: 46.5 — Over (-115), Under (-105)
  • Head-to-Head: Bears are 6-4 against the Rams in their last 10 games.

Complete odds and other NFL Week 1 markets available at BetOnline.ag.

Devon Platana
Devon Platana

After graduating with a Masters degree in Journalism, Devon joined USGS to improve his sports writing skills. As a lifelong sports fan, one of Devon’s favorite things to do is analyze statistics across all sports.