NFL Odds: Lines and Spread for each of Sunday’s Week 2 Games

We are officially more than one week into the 2021 NFL season as a bundle of games are scheduled for this weekend. There are a ton of big matchups scheduled for Sunday, September 19, which means that there’s a lot to keep track of. Fortunately, this betting guide has all of the lines and spreads for each of Sunday’s games in one place, making it easy to know everything that’s important.

Here’s a look at the odds heading into each of this Sunday’s Week 2 matchups, with odds courtesy of Bovada.

NFL Odds: Buffalo Bills vs Miami Dolphins

Odds via Bovada as of Friday, September 17

  • Record: Buffalo Bills (0-1) vs Miami Dolphins (1-0)
  • Start time: 1 p.m. EST
  • Moneyline: Bills (-180) vs Dolphins (+155)
  • Spread: Bills -3.5 (-105) vs Dolphins +3.5 (-115)
  • Total: 47.5 — Over (-110), Under (-110)
  • Head-to-Head: Bills are 7-3 against the Dolphins in their last 10 games.

Cincinnati Bengals vs Chicago Bears

Odds via Bovada as of Friday, September 17

  • Record: Cincinnati Bengals (1-0) vs Chicago Bears (0-1)
  • Start time: 1 p.m. EST
  • Moneyline: Bengals (+110) vs Bears (-130)
  • Spread: Bengals +2.0 (-110) vs Bears -2.0 (-110)
  • Total: 45.0 — Over (-110), Under (-110)
  • Head-to-Head: Bengals are 3-3 against the Bears in their last six games.

Denver Broncos vs Jacksonville Jaguars

Odds via Bovada as of Friday, September 17

  • Record: Denver Broncos (1-0) vs Jacksonville Jaguars (0-1)
  • Start time: 1 p.m. EST
  • Moneyline: Broncos (-270) vs Jaguars (+220)
  • Spread: Broncos -6.0 (-115) vs Jaguars +6.0 (-105)
  • Total: 45.0 — Over (-110), Under (-110)
  • Head-to-Head: Jaguars are 6-4 against the Broncos in their last 10 games.

NFL Odds: Houston Texans vs Cleveland Browns

Odds via Bovada as of Friday, September 17

  • Record: Houston Texans (0-1) vs Cleveland Browns (0-1)
  • Start time: 1 p.m. EST
  • Moneyline: Texans (+475) vs Browns (-700)
  • Spread: Texans +13.0 (-110) vs Browns -13.0 (-110)
  • Total: 48.0 — Over (-110), Under (-110)
  • Head-to-Head: Texans are 7-3 against the Browns in their last 10 games.

Las Vegas Raiders vs Pittsburgh Steelers

Odds via Bovada as of Friday, September 17

  • Record: Las Vegas Raiders (1-0) vs Pittsburgh Steelers (1-0)
  • Start time: 1 p.m. EST
  • Moneyline: Raiders (+220) vs Steelers (-270)
  • Spread: Raiders +6.5 (-110) vs Steelers -6.5 (-110)
  • Total: 47.0 — Over (-110), Under (-110)
  • Head-to-Head: Raiders are 6-4 against the Steelers in their last 10 games.

Los Angeles Rams vs Indianapolis Colts

Odds via Bovada as of Friday, September 17

  • Record: Los Angeles Rams (1-0) vs Indianapolis Colts (0-1)
  • Start time: 1 p.m. EST
  • Moneyline: Rams (-195) vs Colts (+165)
  • Spread: Rams -3.5 (-115) vs Colts +3.5 (-105)
  • Total: 48.0 — Over (-110), Under (-110)
  • Head-to-Head: Rams are 3-3 against the Colts in their last six games.

NFL Odds: New England Patriots vs New York Jets

Odds via Bovada as of Friday, September 17

  • Record: New England Patriots (0-1) vs New York Jets (0-1)
  • Start time: 1 p.m. EST
  • Moneyline: Patriots (-250) vs Jets (+210)
  • Spread: Patriots -6.0 (-110) vs Jets +6.0 (-110)
  • Total: 43.0 — Over (-110), Under (-110)
  • Head-to-Head: Patriots are 10-0 against the Jets in their last 10 games.

New Orleans Saints vs Carolina Panthers

Odds via Bovada as of Friday, September 17

  • Record: New Orleans Saints (1-0) vs Carolina Panthers (1-0)
  • Start time: 1 p.m. EST
  • Moneyline: Saints (-185) vs Panthers (+160)
  • Spread: Saints -3.5 (-110) vs Panthers +3.5 (-110)
  • Total: 44.5 — Over (-110), Under (-110)
  • Head-to-Head: Saints are 8-2 against the Panthers in their last 10 games.

San Francisco 49ers vs Philadelphia Eagles

Odds via Bovada as of Friday, September 17

  • Record: San Francisco 49ers (1-0) vs Philadelphia Eagles (1-0)
  • Start time: 1 p.m. EST
  • Moneyline: 49ers (-150) vs Eagles (+130)
  • Spread: 49ers -3.0 (-105) vs Eagles +3.0 (-115)
  • Total: 50.0 — Over (-105), Under (-115)
  • Head-to-Head: Eagles are 7-3 against the 49ers in their last 10 games.

NFL Odds: Atlanta Falcons vs Tampa Bay Buccaneers

Odds via Bovada as of Friday, September 17

  • Record: Atlanta Falcons (0-1) vs Tampa Bay Buccaneers (1-0)
  • Start time: 4:05 p.m. EST
  • Moneyline: Falcons (+500) vs Buccaneers (-750)
  • Spread: Falcons +12.5 (-110) vs Buccaneers -12.5 (-110)
  • Total: 52.0 — Over (-110), Under (-110)
  • Head-to-Head: Falcons are 6-4 against the Buccaneers in their last 10 games.

Minnesota Vikings vs Arizona Cardinals

Odds via Bovada as of Friday, September 17

  • Record: Minnesota Vikings (0-1) vs Arizona Cardinals (1-0)
  • Start time: 4:05 p.m. EST
  • Moneyline: Vikings (+165) vs Cardinals (-195)
  • Spread: Vikings +3.5 (-105) vs Cardinals -3.5 (-115)
  • Total: 51.0 — Over (-105), Under (-115)
  • Head-to-Head: Vikings are 7-3 against the Cardinals in their last 10 games.

Dallas Cowboys vs Los Angeles Chargers

Odds via Bovada as of Friday, September 17

  • Record: Dallas Cowboys (0-1) vs Los Angeles Chargers (1-0)
  • Start time: 4:25 p.m. EST
  • Moneyline: Cowboys (+155) vs Chargers (-180)
  • Spread: Cowboys +3.5 (-115) vs Chargers -3.5 (-105)
  • Total: 55.0 — Over (-115), Under (-105)
  • Head-to-Head: Chargers are 4-2 against the Cowboys in their last six games.

NFL Odds: Tennessee Titans vs Seattle Seahawks

Odds via Bovada as of Friday, September 17

  • Record: Tennessee Titans (0-1) vs Seattle Seahawks (1-0)
  • Start time: 4:25 p.m. EST
  • Moneyline: Titans (+230) vs Seahawks (-280)
  • Spread: Titans +6.5 (-110) vs Seahawks -6.5 (-110)
  • Total: 54.0 — Over (-110), Under (-110)
  • Head-to-Head: Seahawks are 5-2 against the Titans in their last seven games.

Sunday Night Football Odds: Kansas City Chiefs vs Baltimore Ravens

Odds via Bovada as of Friday, September 17

  • Record: Kansas City Chiefs (1-0) vs Baltimore Ravens (0-1)
  • Start time: 4:25 p.m. EST
  • Moneyline: Chiefs (-200) vs Ravens (+170)
  • Spread: Chiefs -4.0 (-115) vs Ravens +4.0 (-105)
  • Total: 54.5 — Over (-110), Under (-110)
  • Head-to-Head: Chiefs are 6-4 against the Ravens in their last 10 games.

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Devon Platana
After graduating with a Masters degree in Journalism, Devon joined USGS to improve his sports writing skills. As a lifelong sports fan, one of Devon’s favorite things to do is analyze statistics across all sports.