NFL Odds: Lines & Spread for Saturday & Sunday’s Week 16 Games

We’re officially at Week 16 of the 2021 NFL season as a bundle of games are scheduled for this weekend. There are a ton of exciting matchups going down this weekend, which means that there’s a lot to keep track of. Fortunately, this betting guide has all of the lines and spreads for each of Saturday and Sunday’s games in one place, making it easy to know everything that’s important for this week’s matchups.

Here’s a look at the odds heading into each of this Saturday and Sunday’s Week 16 matchups, with odds courtesy of BetOnline.

NFL Week 16: Browns vs Packers Odds

Odds via BetOnline as of Thursday, December 23

  • Record: Cleveland Browns (7-7) vs Green Bay Packers (11-3)
  • Start time: Saturday, Dec. 25 @ 4:30 p.m. EST
  • Moneyline: Browns (+290) vs Packers (-360)
  • Spread: Browns +7.5 (-105) vs Packers -7.5 (-115)
  • Total: 45.5 — Over (-110), Under (-110)
  • Head-to-Head: Packers are 4-1 against the Browns in their last five games.

Colts vs Cardinals Odds

Odds via BetOnline as of Thursday, December 16

  • Record: Indianapolis Colts (8-6) vs Arizona Cardinals (10-4)
  • Start time: Saturday, Dec. 25 @ 8:15 p.m. EST
  • Moneyline: Colts (-104) vs Cardinals (-116)
  • Spread: Colts +1.0 (-110) vs Cardinals -1.0 (-110)
  • Total: 49.0 — Over (-110), Under (-110)
  • Head-to-Head: Colts are 3-2 against the Cardinals in their last five games.

Jaguars vs Jets Odds

Odds via BetOnline as of Thursday, December 23

  • Record: Jacksonville Jaguars (2-12) vs New York Jets (3-11)
  • Start time: Sunday, Dec. 26 @ 1 p.m. EST
  • Moneyline: Jaguars (N/A) vs Jets (N/A)
  • Spread: Jaguars N/A (N/A) vs Jets N/A (N/A)
  • Total: N/A — Over (N/A), Under (N/A)
  • Head-to-Head: Jaguars are 5-5 against the Jets in their last 10 games.

NFL Week 16: Buccaneers vs Panthers Odds

Odds via BetOnline as of Thursday, December 23

  • Record: Tampa Bay Buccaneers (10-4) vs Carolina Panthers (5-9)
  • Start time: Sunday, Dec. 26 @ 1 p.m. EST
  • Moneyline: Buccaneers (-450) vs Panthers (+360)
  • Spread: Buccaneers -10.0 (-110) vs Panthers +10.0 (-110)
  • Total: 43.5 — Over (-115), Under (-105)
  • Head-to-Head: Buccaneers are 6-4 against the Panthers in their last 10 games.

Chargers vs Texans Odds

Odds via BetOnline as of Thursday, December 23

  • Record: Los Angeles Chargers (8-6) vs Houston Texans (3-11)
  • Start time: Sunday, Dec. 26 @ 1 p.m. EST
  • Moneyline: Buccaneers (-425) vs Panthers (+345)
  • Spread: Buccaneers -10.0 (-110) vs Panthers +10.0 (-110)
  • Total: 45.5 — Over (-110), Under (-110)
  • Head-to-Head: Chargers are 5-2 against the Texans in their last seven games.

Lions vs Falcons Odds

Odds via BetOnline as of Thursday, December 23

  • Record: Detroit Lions (2-11-1) vs Atlanta Falcons (6-8)
  • Start time: Sunday, Dec. 26 @ 1 p.m. EST
  • Moneyline: Lions (+200) vs Falcons (-240)
  • Spread: Lions +5.5 (-113) vs Falcons -5.5 (-107)
  • Total: 43.0 — Over (-110), Under (-110)
  • Head-to-Head: Falcons are 6-4 against the Lions in their last 10 games.

NFL Week 16: Ravens vs Bengals Odds

Odds via BetOnline as of Thursday, December 23

  • Record: Baltimore Ravens (8-6) vs Cincinnati Bengals (8-6)
  • Start time: Sunday, Dec. 26 @ 1 p.m. EST
  • Moneyline: Ravens (+130) vs Bengals (-150)
  • Spread: Ravens +3.0 (-113) vs Bengals -3.0 (-107)
  • Total: 45.5 — Over (-110), Under (-110)
  • Head-to-Head: Ravens are 6-4 against the Bengals in their last 10 games.

Rams vs Vikings Odds

Odds via BetOnline as of Thursday, December 23

  • Record: Los Angeles Rams (10-4) vs Minnesota Vikings (7-7)
  • Start time: Sunday, Dec. 26 @ 1 p.m. EST
  • Moneyline: Rams (-160) vs Vikings (+140)
  • Spread: Rams -3.0 (-108) vs Vikings +3.0 (-112)
  • Total: 49.5 — Over (-110), Under (-110)
  • Head-to-Head: Vikings are 6-4 against the Rams in their last 10 games.

Giants vs Eagles Odds

Odds via BetOnline as of Thursday, December 23

  • Record: New York Giants (4-10) vs Philadelphia Eagles (7-7)
  • Start time: Sunday, Dec. 26 @ 1 p.m. EST
  • Moneyline: Giants (N/A) vs Eagles (N/A)
  • Spread: Giants N/A (N/A) vs Eagles N/A (N/A)
  • Total: N/A — Over (N/A), Under (N/A)
  • Head-to-Head: Eagles are 8-2 against the Giants in their last 10 games.

Bills vs Patriots Odds

Odds via BetOnline as of Thursday, December 23

  • Record: Buffalo Bills (8-6) vs New England Patriots (9-5)
  • Start time: Sunday, Dec. 26 @ 1 p.m. EST
  • Moneyline: Bills (+115) vs Patriots (-135)
  • Spread: Bills +2.5 (-106) vs Patriots -2.5 (-114)
  • Total: 43.0 — Over (-112), Under (-108)
  • Head-to-Head: Patriots are 8-2 against the Bills in their last 10 games.

NFL Week 16: Bears vs Seahawks Odds

Odds via BetOnline as of Thursday, December 23

  • Record: Chicago Bears (4-10) vs Seattle Seahawks (5-9)
  • Start time: Sunday, Dec. 26 @ 4:05 p.m. EST
  • Moneyline: Bears (+235) vs Seahawks (-280)
  • Spread: Bears +6.5 (-110) vs Seahawks -6.5 (-110)
  • Total: 42.5 — Over (-110), Under (-110)
  • Head-to-Head: Bears are 5-5 against the Seahawks in their last 10 games.

Steelers vs Chiefs Odds

Odds via BetOnline as of Thursday, December 23

  • Record: Pittsburgh Steelers (7-6-1) vs Kansas City Chiefs (10-4)
  • Start time: Sunday, Dec. 26 @ 4:25 p.m. EST
  • Moneyline: Steelers (N/A) vs Chiefs (N/A)
  • Spread: Steelers +7.0 (-105) vs Chiefs -7.0 (-115)
  • Total: 45.0 — Over (-110), Under (-110)
  • Head-to-Head: Steelers are 7-3 against the Chiefs in their last 10 games.

Broncos vs Raiders Odds

Odds via BetOnline as of Thursday, December 23

  • Record: Denver Broncos (7-7) vs Las Vegas Raiders (7-7)
  • Start time: Sunday, Dec. 26 @ 4:25 p.m. EST
  • Moneyline: Broncos (N/A) vs Raiders (N/A)
  • Spread: Broncos [Pick ‘Em] (-110) vs Raiders [Pick ‘Em] (-110)
  • Total: 42.0 — Over (-110), Under (-110)
  • Head-to-Head: Raiders are 6-4 against the Broncos in their last 10 games.

NFL Week 16 Sunday Night Football: Washington vs Cowboys Odds

Odds via BetOnline as of Thursday, December 23

  • Record: Washington Football Team (6-8) vs Dallas Cowboys (10-4)
  • Start time: Sunday, Dec. 26 @ 8:20 p.m. EST
  • Moneyline: Washington (N/A) vs Cowboys (N/A)
  • Spread: Washington +11.0 (-110) vs Cowboys -11.0 (-110)
  • Total: 46.5 — Over (-110), Under (-110)
  • Head-to-Head: Cowboys are 7-3 against Washington in their last 10 games.

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Devon Platana
After graduating with a Masters degree in Journalism, Devon joined USGS to improve his sports writing skills. As a lifelong sports fan, one of Devon’s favorite things to do is analyze statistics across all sports.